“Anaemia is an+aemia (no+blood) a condition where in there is decreased oxygen carrying capacity by the blood”.
Red blood cells are those which carry oxygen to different body regions. They have an iron pigment namely haemoglobin to do that.
RBC’s per deciliter of blood is kept constant to aid proper respiration. When RBC count per mm of blood falls, we experience anemia.
But there are many other types of anemia which are caused by different factors.
But the routine type of anemia is seen in women with abnormal menstruation, during pregnancy and also in children with insufficient or poor nutrition.
The oxygen carrying capacity of the blood depends on the hemoglobin portion situated inside red blood cells (RBC’s). So if there is anemia we experience weakness and lack of strength.
These RBC’s are formed in the red bone marrow of the large bones in the body.
They are biconcave in shape and circulate in blood for a span of 120 days.
Latter they get destroyed in liver and spleen as their surface becomes fragile due to wear and tear during circulation for 120 days.
The dead one’s are replaced by the new RBC’s.
The cells formed in the bone marrow are quite large than normal RBC’s and hence vitamins like folic acid and vit-B12 help in their multiplication to RBC’s.
So anemia can occur when there is less volume of blood (in cases like severe bleeding), decrease in RBC count or decreased hemoglobin content due to lack of iron supplement in food.
Types of anemia:
1. Blood Loss Anemia; This happens when there is hemorrhage due to an accident or during delivery etc. Here total blood volume including RBC number is low. This is seen in women in most cases as they lose blood even due to menstrual cycle. This blood loss anemia can be rectified by transfusion.
2. Anaemia due to less RBC count: This is a type of anemia where there is no sufficient number of red blood cells. This is due to lack of production of RBC or excess destruction of RBC.
This type of anemia includes aplastic anemia megaloblastic, pernecious anemia. Further types include genetic related anemic conditions like sickle anaemia, hereditary spherocytosis, erythroblastosis fetalis etc.
For immediate rescue, RBC cells are transfused to the patient. But on the long run, the effort is to enhance new RBC formation.
3. Aplastic anaemia: This is a condition due to damage of bone marrow by radiation or drugs. Hence the bone marrow is unable to produce enough RBC’s required for sufficient oxygenation. In sever cases it may require bone marrow transplants.
4. Megaloblastic Anemia: As the name indicates, the cells formed are very large in size.
This is due to lack of vitamin-12 or folic acid leading to mega RBS. This is happen by improper multiplication of large cells formed in bone marrow.
Hence RBC count is low due to improper cell multiplication and production.
Further due to large size they easily get destroyed and hence their life span is small unlike normal RBC’s 120 days. Thus overall RBC count falls due to lack of above vitamins. This is other wise called pernicious anemia if the Vitamin-B12 is deficient. So it is advised to take vitamin supplements after consulting physician.
5. The genetic or hereditary based anaemia are less common but patient suffer the issue entire life. This condition can be termed as haemolytic anaemia (haemo-related to RBC and Lytic- means breakage) i.e RBC cells formed are broken down before normal life span of 120 days. This destruction in short time leads to decreased RBC count. The destruction is due to their weak or fragile and abnormal structure instead of noramal biconcave. Examples include
6. Sickle cell anaemia: As the name indicates the RBC’s formed are sickle shaped instead of biconcave.
Due to abnormal shape, they are easily susceptible to endoplasmic reticulum destruction in liver and spleen.
Thus their life span is small and less than normal RBC’s of 120 days.
They get destroyed and have short life span so the RBC count remains low leading to anaemia.
7. Spherocytosis anaemia: Here the cells are spherical shaped and they follow the pattern of sickle cell anemia. Similar to above they have short life spans.
8. Decreased Hemoglobin content: Here the RBC cells are devoid of sufficient hemoglobin. This can be due to dietary protein insufficiency or else decreased iron content.
Ex: Hypochromic or microcytic anaemia+ hypo+chromic=less coloured and mircocytic= small cell size. As we see, this is type anemia is due to low iron levels in the body. There is low amounts of hemoglobin due to iron deficiency such that cells are small and blood looks pale.
Types of anemia as per clinical diagnosis:
When blood is examined under microscope, there are three types of anemia like
a) Normocytic anemia
b) megaloblastic anemia &
c) microcytic anemia
Normocytic anemia is one where the Red blood cell size is normal with sufficient levels of hemoglobin. This types of anemia occurs due to decrease in erythrocyte count rather than the changes in RBC. This is cause due to blood loss in injury, menstruation etc in many case. However, it can also be caused due to deficiency of erythropoiten where there is less synthesis or red blood cells in bone marrow.
Megaloblastic anemia is one where the red blood cells enormous in size. They can have sufficient hemoglobin or less. These cells are not fully matured and improperly divided during formation hence look bulky than the normal size.
Microcytic anemia is one where the RBC cells are smaller in size than the normal ones. This is mostly due to insufficient hemoglobin levels.
Symptoms of anemia include:
Mostly symptoms go unnoticed but sometimes there can be
1. Fatigue: Exhaustion due to physical exertion as blood is unable to supply needed oxygen for chemical energy production.
2. Paleness of mucous membranes like that below the eye lids etc.
3. In extreme conditions during exercise, the heart rises the cardiac out put (volume of blood pumped) to meet the excess oxygen demands of body. In doing so there can be chances of cardiac failure and death.
One can avoid anemia by proper diet, leafy vegetable consumption and also iron supplements. If one have vitamin deficiency, it has to be corrected immediately. Sometimes though vitamin-12 is consumed by external supplements, still the gut may not observe it. So it is advised to consult a physician if the symptoms are troublesome. ( Vitamin Shoppe)